Kain Warwick—DeFi OG and founder of Synthetix and Infinex—is back on The Defiant Podcast with Camila Russo for a no-BS conversation at a pivotal moment: Infinex just ran its INX token sale and is heading into its TGE.

In this interview, Camila Russo sits down with Danny Ryan — former Ethereum Foundation researcher and a key leader behind Ethereum’s shift to proof of stake — now Co-Founder & President at Etherealize, to talk about the next big wave for crypto: institutional adoption of Ethereum. Recorded in Buenos Aires during Devconnect, Danny breaks down why the mood inside banks has flipped from “we can’t touch crypto” to “if we don’t adopt it, we’ll be left behind.” We dig into what institutions actually want beyond ETFs, why the biggest opportunity isn’t “tokenizing assets” but rewiring markets from first principles, and why privacy is table stakes for institutional-grade onchain finance.

In this episode of The Defiant Podcast, Chris Storaker sits down with Alex Garn, Chief Product Officer at Borderless, to unpack how stablecoins are quietly transforming cross-border payments — and what it actually takes to move money at scale across jurisdictions.

In this episode of The Defiant podcast, Camila Russo sits down in Buenos Aires (Devconnect) with Marissa Posner (Product, Ethereum Foundation) and Yoav Weiss (security researcher, Ethereum Foundation) to unpack The Trustless Manifesto and the Ethereum Interop Layer (EIL), why “trust assumptions” are quietly creeping into Ethereum’s stack, and what it will take to preserve Ethereum’s core values while making UX actually usable. We dig into the hidden places users are forced to trust intermediaries, from cross-chain interoperability and solvers to something most people never question: RPCs. Then we get practical: the guests walk through the EIL, a new approach to cross-chain UX that aims to deliver one-signature interop without introducing new trust assumptions, plus why the wallet becomes the center of the user’s security model. Finally, we zoom out: how should wallets warn users, what does “walkaway test” really mean, and why institutions may end up being one of the strongest forces pushing crypto toward less counterparty risk.

In this episode of The Defiant Podcast, Uniswap founder Hayden Adams joins us right as the UNIfication (Unification) proposal has moved to a final governance vote—a sweeping plan from Uniswap Labs + the Uniswap Foundation that would activate protocol fees, introduce a programmatic UNI burn, and realign how value accrues across the Uniswap ecosystem.

In this episode of The Defiant podcast we speak with Morgan Krupetsky, VP of OnChain Finance at Ava Labs, to break down one of the most significant shifts happening in crypto today: the rapid institutionalization of blockchain and Avalanche’s strategy to lead it. Morgan walks us through Avalanche’s “real-world adoption first” ethos, explaining how its unique architecture enables enterprises, fintechs, banks, governments, and consumer apps to build purpose-designed blockchains while tapping into a shared liquidity hub.

Robert Leshner — the mind behind Compound, and now the founder of Superstate — believes the next trillion-dollar shift will come from bringing the world’s assets on-chain.

In a world of fast-advancing technology, we are told to trust in our own research. But as the crypto space matures, scams and exploits remain a constant presence. When your assets are gone, they are gone forever, with a near-zero chance of recovery. The old mantra of "Do Your Own Research" falls short against sophisticated threats like address poisoning, advanced malware, and convincing AI deepfakes. How, then, do we build a safer Web3 without sacrificing the decentralized ideals at its core?

In the second episode of Ecosystems: Avalanche, we track the protocol’s trajectory, which included a peak valuation of $13 billion, followed by a period of consolidation and strategic redevelopment.